Detection of Left Ventricular Hypertrophy in Rats Administered a Peroxisome Proliferator–Activated Receptor a/c Dual Agonist Using Natriuretic Peptides and Imaging
نویسندگان
چکیده
1 To whom correspondence should be addressed at Lilly Corporate Center, Indianapolis, IN 46285. Fax: 317-651-6330. E-mail: englesk@lillycom; [email protected]. 2 These authors contributed equally to this study. 3 Present address: Department of Molecular and Anatomical Imaging, Covance Laboratories, Inc., Greenfield, IN 46140. 4 Present address: Animal Studies Area, Covance Laboratories, Inc., Greenfield, IN 46140.
منابع مشابه
Detection of left ventricular hypertrophy in rats administered a peroxisome proliferator-activated receptor alpha/gamma dual agonist using natriuretic peptides and imaging.
Chronic treatment with suprapharmacologic doses of peroxisome proliferator-activated receptor (PPAR) agonists has a known potential for causing left ventricular hypertrophy (LVH). The mechanism by which LVH develops is not well understood nor are biomarkers of it well characterized. Natriuretic peptides are important regulators of cardiac growth, blood volume, and arterial pressure and may be u...
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Background—Peroxisome proliferator-activated receptor(PPAR) is a lipid-activated nuclear receptor that negatively regulates the vascular inflammatory gene response by interacting with transcription factors, nuclear factorB, and AP-1. However, the roles of PPARactivators in endothelin (ET)-1–induced cardiac hypertrophy are not yet known. Methods and Results—First, in cultured neonatal rat cardio...
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BACKGROUND Peroxisome proliferator-activated receptor-alpha (PPAR-alpha) is a lipid-activated nuclear receptor that negatively regulates the vascular inflammatory gene response by interacting with transcription factors, nuclear factor-kappaB, and AP-1. However, the roles of PPAR-alpha activators in endothelin (ET)-1-induced cardiac hypertrophy are not yet known. METHODS AND RESULTS First, in ...
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